{"id":2166,"date":"2025-03-22T12:47:54","date_gmt":"2025-03-22T12:47:54","guid":{"rendered":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=2166"},"modified":"2025-03-22T12:47:54","modified_gmt":"2025-03-22T12:47:54","slug":"genetic-engineering-discusses-the-study-of-mesenchymal-stem-cells-from-the-umbilical-cord-and-the-umbilical-cord-insertion-region-in-cesarean-births-in-iraq","status":"publish","type":"post","link":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=2166","title":{"rendered":"Genetic Engineering Discusses the Study of Mesenchymal Stem Cells from the Umbilical Cord and the Umbilical Cord Insertion Region in Cesarean Births in Iraq"},"content":{"rendered":"

[vc_row][vc_column][vc_column_text]<\/p>\n

The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies at the University of Baghdad<\/strong> discussed the master\u2019s thesis<\/strong> of student Mustafa Abdullah Ali<\/strong>, titled:
“Study of Mesenchymal Stem Cells from the Umbilical Cord and the Umbilical Cord Insertion Region in Cesarean Births in Iraq.”<\/strong>
The research was conducted under the supervision of Assistant Professor Dr. Muhammad Abdul Malik Ali<\/strong>.<\/p>\n

Study Objectives<\/strong><\/h3>\n

The study aimed to isolate and culture<\/strong> two groups of stem cells obtained from the umbilical cord<\/strong> and the point of connection between the umbilical cord and the placenta<\/strong>. It also aimed to compare the levels of stem cells using quantitative polymerase chain reaction (qPCR)<\/strong> to evaluate the expression of stem cell markers (CD90, CD73, and CD105)<\/strong> and assess their osteogenic differentiation ability<\/strong> by introducing differentiation factors.<\/p>\n

Key Findings<\/strong><\/h3>\n

\ud83d\udd2c The study detected the presence of mesenchymal stem cells in the placental plate<\/strong> on the fetal side of the placental tissues, showing promising results through gene expression evaluation.<\/p>\n

It also identified the presence of hematopoietic-like stem cells<\/strong> within the placental plate on the fetal side of the placenta. Gene expression analysis revealed an initial downregulation of mesenchymal stem cell markers<\/strong> after adding osteogenic differentiation factors<\/strong> to LG-DMEM on the sixth day<\/strong> of culture.<\/p>\n

\ud83e\uddec The study confirmed that the placenta is a valuable source<\/strong> of both mesenchymal and hematopoietic stem cells<\/strong>, depending on the specific region from which they are isolated.<\/p>\n

Recommendations<\/strong><\/h3>\n
    \n
  • Comparative studies<\/strong> should be conducted to evaluate similarities and differences<\/strong> in the abundance and characteristics of mesenchymal stem cells from different regions<\/strong> of the placenta and umbilical cord<\/strong> in humans. This will enhance our understanding of their unique properties<\/strong> and potential applications<\/strong> in regenerative medicine.<\/li>\n
  • Enzymatic methods<\/strong> should be improved to enrich placental mesenchymal stem cells<\/strong>, as they have proven more effective compared to mechanical methods, which may stress the cells and affect their viability<\/strong>.<\/li>\n
  • Encouraging and supporting stem cell research initiatives<\/strong> is essential, given their vast potential for developing stem cell banks<\/strong>, which could serve as valuable resources for cellular therapy and advanced medical research in Iraq<\/strong>.<\/li>\n<\/ul>\n

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