{"id":2417,"date":"2025-07-29T22:59:55","date_gmt":"2025-07-29T22:59:55","guid":{"rendered":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=2417"},"modified":"2025-08-21T01:02:23","modified_gmt":"2025-08-21T01:02:23","slug":"the-institute-of-genetic-engineering-discusses-the-evaluation-of-tecoma-extract-effectiveness-as-an-antimicrobial-agent-against-multidrug-resistant-pseudomonas-aeruginosa-and-its-impact-on-the-gene-ex","status":"publish","type":"post","link":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=2417","title":{"rendered":"The Institute of Genetic Engineering Discusses the Evaluation of Tecoma Extract Effectiveness as an Antimicrobial Agent Against Multidrug-Resistant Pseudomonas aeruginosa and Its Impact on the Gene Expression of mexA and mexB"},"content":{"rendered":"

[vc_row][vc_column][vc_column_text]<\/p>\n

The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies at the University of Baghdad discussed the master’s thesis of student Yahya Mohammed Faleh, titled: \u201cEvaluation of the Effectiveness of Tecoma<\/em> Plant Extract as an Antimicrobial Agent Against Multidrug-Resistant Pseudomonas aeruginosa<\/em> and Its Impact on the Gene Expression of mexA<\/em> and mexB<\/em>\u201d, under the supervision of Asst. Prof. Dr. Maha Ibrahim Saleh.<\/span><\/p>\n

The study aimed to evaluate the antibacterial activity of yellow Tecoma<\/em> leaf extract against Pseudomonas aeruginosa<\/em> isolates and to investigate the gene expression levels of mexA<\/em> and mexB<\/em> in Pseudomonas aeruginosa<\/em> before and after treatment with the ethanolic extract of Tecoma<\/em> leaves.<\/span><\/p>\n

A total of 100 clinical samples were collected from burn and wound patients attending treatment at Al-Nasiriya General Hospital, Thi-Qar Province, between September 2024 and January 2025.<\/span><\/p>\n

The results showed that the isolates were resistant to most of the antibiotics tested in this study, and ten multidrug-resistant isolates were selected for further analysis.<\/span><\/p>\n

Yellow Tecoma<\/em> leaves were collected from the garden of the Veterinary Medicine Complex, University of Baghdad, and the ethanolic extract was prepared using a magnetic stirring method.<\/span><\/p>\n

The antioxidant activity assay revealed free radical scavenging rates of 95.70, 91.87, 76.35, 68.59, and 45.11% at concentrations of 10, 5, 2.5, 1.25, and 0.625 mg\/ml, respectively.<\/span><\/p>\n

The study concluded that the genes mexA<\/em> and mexB<\/em> were present in all selected isolates.<\/span><\/p>\n

It also recommended that, given the significant reduction in the gene expression levels of mexA<\/em> and mexB<\/em> after treatment with the ethanolic extract compared to untreated isolates, the extract likely inhibits the efflux pump system responsible for antibiotic resistance in Pseudomonas aeruginosa<\/em>.<\/span><\/p>\n

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