{"id":2559,"date":"2025-09-12T19:12:25","date_gmt":"2025-09-12T19:12:25","guid":{"rendered":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=2559"},"modified":"2025-09-12T19:12:25","modified_gmt":"2025-09-12T19:12:25","slug":"genetic-engineering-discusses-a-phd-dissertation-on-the-association-between-genetic-polymorphisms-and-gene-expression-of-egfr-and-epcam-as-well-as-the-gene-expression-of-mirna-122-in-relation-to-live","status":"publish","type":"post","link":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=2559","title":{"rendered":"Genetic Engineering discusses a PhD dissertation on the association between genetic polymorphisms and gene expression of EGFR and EpCAM, as well as the gene expression of miRNA-122 in relation to liver cancer."},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<p style=\"text-align: justify;\" data-start=\"0\" data-end=\"435\"><span style=\"font-size: 18px;\">The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies at the University of Baghdad discussed the PhD dissertation of Khalid Rasheed Majid, entitled:<\/span><br data-start=\"178\" data-end=\"181\" \/><span style=\"font-size: 18px;\">\u201cThe Association between Genetic Polymorphisms and Gene Expression of EGFR and EpCAM, and the Gene Expression of miRNA-122 with Liver Cancer in Iraqi Patients with Hepatitis B Virus Infection\u201d, supervised by Asst. Prof. Dr. Weam Ahmed Al-Ameli.<\/span><\/p>\n<p style=\"text-align: justify;\" data-start=\"437\" data-end=\"789\"><span style=\"font-size: 18px;\">The study aimed to determine the role of the epidermal growth factor receptor (EGFR) gene and the epithelial cell adhesion molecule (EpCAM) gene, in addition to the roles of miR-122 and miR-let7a-1, in the development of hepatocellular carcinoma (HCC) caused by chronic hepatitis B virus (CHB) infection in a sample of Iraqi patients.<\/span><\/p>\n<p style=\"text-align: justify;\" data-start=\"791\" data-end=\"1248\"><span style=\"font-size: 18px;\">The results showed that the expression of the EGFR gene was elevated in both HCC and CHB patients (2.04-fold and 2.47-fold, respectively), as well as the EpCAM gene (1.4-fold and 1.8-fold, respectively), compared to healthy controls (1.00). In contrast, the expression of miR-122 and miR-let7a-1 was downregulated in HCC (0.26 and 0.19-fold, respectively) and in CHB (0.81 and 0.21-fold, respectively), compared to healthy controls (1.00).<\/span><\/p>\n<p style=\"text-align: justify;\" data-start=\"1250\" data-end=\"1500\" data-is-last-node=\"\" data-is-only-node=\"\"><span style=\"font-size: 18px;\">The study concluded, based on ROC analysis, that miR-let7a-1 in HCC and CHB patients, and miR-122 in HCC patients, demonstrated the highest diagnostic performance, making them promising candidates as specific biomarkers for HCC and CHB.<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;2563&#8243; img_size=&#8221;large&#8221; alignment=&#8221;center&#8221; onclick=&#8221;img_link_large&#8221; css=&#8221;&#8221;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;2561&#8243; img_size=&#8221;large&#8221; alignment=&#8221;center&#8221; onclick=&#8221;img_link_large&#8221; css=&#8221;&#8221;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies at the University of Baghdad discussed the PhD dissertation &#8230; <\/p>\n","protected":false},"author":37,"featured_media":2562,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[14,17,7],"tags":[],"class_list":["post-2559","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-archives","category-last-news","category-a-a"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - 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