{"id":2983,"date":"2026-02-25T09:12:58","date_gmt":"2026-02-25T09:12:58","guid":{"rendered":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=2983"},"modified":"2026-02-27T09:16:03","modified_gmt":"2026-02-27T09:16:03","slug":"genetic-engineering-discusses-a-study-of-the-phenotypic-and-genotypic-drug-resistance-patterns-of-mycobacterium-tuberculosis-strains-from-the-tuberculosis-complex-isolated-from-humans-and-animals","status":"publish","type":"post","link":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=2983","title":{"rendered":"Genetic Engineering Discusses a Study of the Phenotypic and Genotypic Drug Resistance Patterns of Mycobacterium tuberculosis Strains from the Tuberculosis Complex Isolated from Humans and Animals."},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<p style=\"text-align: justify;\" data-start=\"0\" data-end=\"139\"><span style=\"font-size: 18px;\">The <span class=\"hover:entity-accent entity-underline inline cursor-pointer align-baseline\"><span class=\"whitespace-normal\">Institute of Genetic Engineering and Biotechnology for Postgraduate Studies<\/span><\/span> discussed the PhD dissertation submitted by doctoral candidate Salam Hadi Fayyad, entitled:<\/span><\/p>\n<p style=\"text-align: justify;\" data-start=\"141\" data-end=\"357\"><span style=\"font-size: 18px;\">\u201cStudy of Phenotypic and Genotypic Drug Resistance Patterns of <em data-start=\"206\" data-end=\"234\">Mycobacterium tuberculosis<\/em> Strains from the Tuberculosis Complex Isolated from Humans and Animals, and Their Association with Genetic Mutations\u201d,<\/span><\/p>\n<p style=\"text-align: justify;\" data-start=\"359\" data-end=\"524\"><span style=\"font-size: 18px;\">under the supervision of Professor Dr. Mona Turki Al-Mousawi and external supervisor Professor Dr. Ahmed Asmar Mankhi from the <span class=\"hover:entity-accent entity-underline inline cursor-pointer align-baseline\"><span class=\"whitespace-normal\">National Tuberculosis Institute<\/span><\/span>.<\/span><\/p>\n<p style=\"text-align: justify;\" data-start=\"526\" data-end=\"1254\"><span style=\"font-size: 18px;\">The study aimed to isolate and identify members of the <em data-start=\"581\" data-end=\"609\">Mycobacterium tuberculosis<\/em> complex (MTBC) resistant to first- and second-line anti-tuberculosis drugs from positive TB samples, using conventional techniques including culture, Ziehl\u2013Neelsen (ZN) staining, interferon-gamma release assays (IGRA), drug susceptibility testing (DST), molecular analysis of TB-associated proteins (LPA), and evaluating the accuracy of rapid molecular tests such as GeneXpert MTB\/RIF, Xpert MTB\/XDR, and the new 10-color Xpert MTB\/XDR, compared to conventional techniques. The study also aimed to identify resistance-associated genes and detect genetic mutations linked to resistance to first- and second-line injectable anti-TB drugs.<\/span><\/p>\n<p style=\"text-align: justify;\" data-start=\"1256\" data-end=\"1510\"><span style=\"font-size: 18px;\">The dissertation recommended enhancing the use of rapid molecular diagnostics (GeneXpert MTB\/RIF, Xpert MTB\/XDR, and LPA) for early detection of drug-resistant TB, which can reduce the incidence of disease associated with delayed diagnosis and treatment.<\/span><\/p>\n<p style=\"text-align: justify;\" data-start=\"1512\" data-end=\"1857\"><span style=\"font-size: 18px;\">It also advised improving the monitoring of drug-resistant TB strains through continuous surveillance of mutations in the rpoB, katG, inhA, gyrA, and rrs genes, and conducting periodic screening for latent TB infections in high-risk groups, such as livestock breeders, animal care workers, and individuals in direct contact with animals.<\/span><\/p>\n<p style=\"text-align: justify;\" data-start=\"1859\" data-end=\"2198\"><span style=\"font-size: 18px;\">Furthermore, the study recommended expanding research focusing on environmental, occupational, and genetic risk factors associated with TB spread and drug resistance, ensuring proper management of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB), and strict adherence to treatment protocols and regular follow-up.<\/span><\/p>\n<p style=\"text-align: justify;\" data-start=\"2200\" data-end=\"2504\" data-is-last-node=\"\" data-is-only-node=\"\"><span style=\"font-size: 18px;\">The study emphasized the necessity of collaboration between relevant institutions under the Ministries of Health and Agriculture to establish a national program for controlling genetically modified TB, particularly bovine TB transmissible to humans, and implementing stricter biosafety measures on farms.<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;2986&#8243; img_size=&#8221;large&#8221; alignment=&#8221;center&#8221; onclick=&#8221;img_link_large&#8221; css=&#8221;&#8221;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;2987&#8243; img_size=&#8221;large&#8221; alignment=&#8221;center&#8221; onclick=&#8221;img_link_large&#8221; css=&#8221;&#8221;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies discussed the PhD dissertation submitted by doctoral candidate Salam &#8230; <\/p>\n","protected":false},"author":37,"featured_media":2985,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[14,17,7],"tags":[],"class_list":["post-2983","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-archives","category-last-news","category-a-a"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - 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