{"id":3181,"date":"2026-09-10T17:24:07","date_gmt":"2026-09-10T17:24:07","guid":{"rendered":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181"},"modified":"2026-09-10T17:24:07","modified_gmt":"2026-09-10T17:24:07","slug":"the-institute-of-genetic-engineering-and-biotechnology-for-postgraduate-studies-discusses-a-masters-thesis-on-the-effect-of-a-histidine-kinase-inhibitor-on-gene-expression-in-staphylococcus-aureus","status":"publish","type":"post","link":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181","title":{"rendered":"The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies Discusses a Master’s Thesis on the Effect of a Histidine Kinase Inhibitor on Gene Expression in Staphylococcus aureus"},"content":{"rendered":"

[vc_row][vc_column][vc_column_text]<\/p>\n

The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies at the University of Baghdad discussed the Master\u2019s thesis entitled \u201cEffect of a Histidine Kinase Inhibitor on the Expression of the SaeRS Regulator and Adhesion Genes (fnbA and fnbB) in Clinical Isolates of Staphylococcus aureus<\/em>,\u201d submitted by Master\u2019s student Inas Khalid Mizaal under the supervision of Assistant Professor Dr. Abdul Amir Mohammed Gharib.<\/span><\/p>\n

The study aimed to evaluate the effect of phenazopyridine hydrochloride (PP-HCl), as a potential histidine kinase inhibitor, at sub-inhibitory concentrations on the expression of the genes saeS and saeR, which constitute the two-component SaeRS system, as well as the adhesion-associated genes fnbA and fnbB in clinical isolates of Staphylococcus aureus<\/em>. The study also evaluated the effect of the compound alone and in combination with the antibiotic ciprofloxacin on biofilm formation.<\/span><\/p>\n

The study recommended conducting further investigations using S. aureus<\/em> isolates from different clinical sources to confirm the effects of PP-HCl and determine whether its inhibitory effects on biofilm formation and adhesion-gene expression can be generalized. The evaluation should also be expanded to include the protein and functional levels of the SaeRS\u2013FnBP pathway, in order to elucidate the potential molecular mechanism underlying the observed effects and identify the stage at which the compound interferes with biofilm formation.<\/span><\/p>\n

The study also recommended evaluating PP-HCl in combination with selected antibacterial or antibiofilm plant-derived compounds and extracts, and investigating the nature of their interactions and the possibility of synergistic effects. Such studies may contribute in the future to the development of adjunctive therapeutic strategies against infections caused by Staphylococcus aureus<\/em>.<\/span><\/p>\n

[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=”1\/2″][vc_single_image image=”3190″ img_size=”large” alignment=”center” onclick=”img_link_large” css=””][\/vc_column][vc_column width=”1\/2″][vc_single_image image=”3190″ img_size=”large” alignment=”center” onclick=”img_link_large” css=””][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row][vc_column][vc_column_text] The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies at the University of Baghdad discussed the Master\u2019s thesis … <\/p>\n","protected":false},"author":37,"featured_media":3192,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[14,17,7],"tags":[],"class_list":["post-3181","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-archives","category-last-news","category-a-a"],"yoast_head":"\nThe Institute of Genetic Engineering and Biotechnology for Postgraduate Studies Discusses a Master's Thesis on the Effect of a Histidine Kinase Inhibitor on Gene Expression in Staphylococcus aureus - Institute of Genetic Engineering and Biotechnology for Postgraduate Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies Discusses a Master's Thesis on the Effect of a Histidine Kinase Inhibitor on Gene Expression in Staphylococcus aureus - Institute of Genetic Engineering and Biotechnology for Postgraduate Studies\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text] The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies at the University of Baghdad discussed the Master\u2019s thesis ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181\" \/>\n<meta property=\"og:site_name\" content=\"Institute of Genetic Engineering and Biotechnology for Postgraduate Studies\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/groups\/565175287525365\/?mibextid=6NoCDW\" \/>\n<meta property=\"article:published_time\" content=\"2026-09-10T17:24:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/en.ige.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/98\/2026\/09\/1101a.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"1371\" \/>\n\t<meta property=\"og:image:height\" content=\"1028\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"ige\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"ige\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/?p=3181#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/?p=3181\"},\"author\":{\"name\":\"ige\",\"@id\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/#\\\/schema\\\/person\\\/16b77148763900db5d74e76dd1977022\"},\"headline\":\"The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies Discusses a Master’s Thesis on the Effect of a Histidine Kinase Inhibitor on Gene Expression in Staphylococcus aureus\",\"datePublished\":\"2026-09-10T17:24:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/?p=3181\"},\"wordCount\":347,\"image\":{\"@id\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/?p=3181#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/wp-content\\\/uploads\\\/sites\\\/98\\\/2026\\\/09\\\/1101a.jpeg\",\"articleSection\":[\"Archives\",\"latest News\",\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/?p=3181\",\"url\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/?p=3181\",\"name\":\"The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies Discusses a Master's Thesis on the Effect of a Histidine Kinase Inhibitor on Gene Expression in Staphylococcus aureus - Institute of Genetic Engineering and Biotechnology for Postgraduate Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/?p=3181#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/?p=3181#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/wp-content\\\/uploads\\\/sites\\\/98\\\/2026\\\/09\\\/1101a.jpeg\",\"datePublished\":\"2026-09-10T17:24:07+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/#\\\/schema\\\/person\\\/16b77148763900db5d74e76dd1977022\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/?p=3181#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/?p=3181\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/?p=3181#primaryimage\",\"url\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/wp-content\\\/uploads\\\/sites\\\/98\\\/2026\\\/09\\\/1101a.jpeg\",\"contentUrl\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/wp-content\\\/uploads\\\/sites\\\/98\\\/2026\\\/09\\\/1101a.jpeg\",\"width\":1371,\"height\":1028},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/?p=3181#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies Discusses a Master’s Thesis on the Effect of a Histidine Kinase Inhibitor on Gene Expression in Staphylococcus aureus\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/#website\",\"url\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/\",\"name\":\"Institute of Genetic Engineering and Biotechnology for Postgraduate Studies\",\"description\":\"University of Baghdad\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/#\\\/schema\\\/person\\\/16b77148763900db5d74e76dd1977022\",\"name\":\"ige\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/aedfb3cbf9eb9c33030c4faa5a534c258309f0967797af8f00e347739e1b8433?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/aedfb3cbf9eb9c33030c4faa5a534c258309f0967797af8f00e347739e1b8433?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/aedfb3cbf9eb9c33030c4faa5a534c258309f0967797af8f00e347739e1b8433?s=96&d=mm&r=g\",\"caption\":\"ige\"},\"url\":\"https:\\\/\\\/en.ige.uobaghdad.edu.iq\\\/?author=37\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies Discusses a Master's Thesis on the Effect of a Histidine Kinase Inhibitor on Gene Expression in Staphylococcus aureus - Institute of Genetic Engineering and Biotechnology for Postgraduate Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181","og_locale":"en_US","og_type":"article","og_title":"The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies Discusses a Master's Thesis on the Effect of a Histidine Kinase Inhibitor on Gene Expression in Staphylococcus aureus - Institute of Genetic Engineering and Biotechnology for Postgraduate Studies","og_description":"[vc_row][vc_column][vc_column_text] The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies at the University of Baghdad discussed the Master\u2019s thesis ...","og_url":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181","og_site_name":"Institute of Genetic Engineering and Biotechnology for Postgraduate Studies","article_publisher":"https:\/\/www.facebook.com\/groups\/565175287525365\/?mibextid=6NoCDW","article_published_time":"2026-09-10T17:24:07+00:00","og_image":[{"width":1371,"height":1028,"url":"https:\/\/en.ige.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/98\/2026\/09\/1101a.jpeg","type":"image\/jpeg"}],"author":"ige","twitter_card":"summary_large_image","twitter_misc":{"Written by":"ige","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181#article","isPartOf":{"@id":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181"},"author":{"name":"ige","@id":"https:\/\/en.ige.uobaghdad.edu.iq\/#\/schema\/person\/16b77148763900db5d74e76dd1977022"},"headline":"The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies Discusses a Master’s Thesis on the Effect of a Histidine Kinase Inhibitor on Gene Expression in Staphylococcus aureus","datePublished":"2026-09-10T17:24:07+00:00","mainEntityOfPage":{"@id":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181"},"wordCount":347,"image":{"@id":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181#primaryimage"},"thumbnailUrl":"https:\/\/en.ige.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/98\/2026\/09\/1101a.jpeg","articleSection":["Archives","latest News","News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181","url":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181","name":"The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies Discusses a Master's Thesis on the Effect of a Histidine Kinase Inhibitor on Gene Expression in Staphylococcus aureus - Institute of Genetic Engineering and Biotechnology for Postgraduate Studies","isPartOf":{"@id":"https:\/\/en.ige.uobaghdad.edu.iq\/#website"},"primaryImageOfPage":{"@id":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181#primaryimage"},"image":{"@id":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181#primaryimage"},"thumbnailUrl":"https:\/\/en.ige.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/98\/2026\/09\/1101a.jpeg","datePublished":"2026-09-10T17:24:07+00:00","author":{"@id":"https:\/\/en.ige.uobaghdad.edu.iq\/#\/schema\/person\/16b77148763900db5d74e76dd1977022"},"breadcrumb":{"@id":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181#primaryimage","url":"https:\/\/en.ige.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/98\/2026\/09\/1101a.jpeg","contentUrl":"https:\/\/en.ige.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/98\/2026\/09\/1101a.jpeg","width":1371,"height":1028},{"@type":"BreadcrumbList","@id":"https:\/\/en.ige.uobaghdad.edu.iq\/?p=3181#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/en.ige.uobaghdad.edu.iq\/"},{"@type":"ListItem","position":2,"name":"The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies Discusses a Master’s Thesis on the Effect of a Histidine Kinase Inhibitor on Gene Expression in Staphylococcus aureus"}]},{"@type":"WebSite","@id":"https:\/\/en.ige.uobaghdad.edu.iq\/#website","url":"https:\/\/en.ige.uobaghdad.edu.iq\/","name":"Institute of Genetic Engineering and Biotechnology for Postgraduate Studies","description":"University of Baghdad","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/en.ige.uobaghdad.edu.iq\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/en.ige.uobaghdad.edu.iq\/#\/schema\/person\/16b77148763900db5d74e76dd1977022","name":"ige","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/aedfb3cbf9eb9c33030c4faa5a534c258309f0967797af8f00e347739e1b8433?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/aedfb3cbf9eb9c33030c4faa5a534c258309f0967797af8f00e347739e1b8433?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/aedfb3cbf9eb9c33030c4faa5a534c258309f0967797af8f00e347739e1b8433?s=96&d=mm&r=g","caption":"ige"},"url":"https:\/\/en.ige.uobaghdad.edu.iq\/?author=37"}]}},"modified_by":"ige","_links":{"self":[{"href":"https:\/\/en.ige.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts\/3181","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/en.ige.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/en.ige.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/en.ige.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/users\/37"}],"replies":[{"embeddable":true,"href":"https:\/\/en.ige.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3181"}],"version-history":[{"count":1,"href":"https:\/\/en.ige.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts\/3181\/revisions"}],"predecessor-version":[{"id":3193,"href":"https:\/\/en.ige.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts\/3181\/revisions\/3193"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/en.ige.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/media\/3192"}],"wp:attachment":[{"href":"https:\/\/en.ige.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3181"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/en.ige.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3181"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/en.ige.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3181"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}