The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies discussed the PhD dissertation submitted by doctoral candidate Hatim Mohammed Hadeed, entitled:
“Computational and Molecular Study of the Most Abundant Non-Coding RNAs and Their Effect on HIF-1 Gene Expression in Breast Cancer Patients”,
under the supervision of Professor Dr. Marib Nazih Rasheed and external supervisor Professor Dr. Ahmed Abdul Jabbar Suleiman.
The study aimed to identify miRNA and lncRNA molecules involved in hypoxia at different stages of breast cancer and to select the most influential ones to investigate their role in HIF-1A gene expression during cancer progression.
The study recommended highlighting the potential role of miRNAs, lncRNAs, and HIF-1A as promising biomarkers in breast cancer. Based on these results, it suggested further exploration of miRNAs and lncRNAs to validate the association between these ncRNAs and HIF-1A expression in both primary and metastatic breast cancer samples.
It also emphasized the need for additional studies in larger, multicenter cohorts to confirm the diagnostic and predictive value of these markers across diverse patient groups. Integrating miRNA, lncRNA, and HIF-1A expression profiles with established clinical-pathological features and molecular markers (such as ER, PR, and HER2) could enhance their predictive accuracy and clinical relevance.
Finally, the study stressed the importance of applying advanced bioinformatics and multi-omics approaches to identify regulatory networks involving miRNAs, lncRNAs, HIF-1A, and their downstream target genes.
