The Institute of Genetic Engineering and Biotechnology for Postgraduate Studies / University of Baghdad discussed the master’s thesis of the student “Duha Jamal Hamoud,” entitled:
“The relationship between recurrent atopic dermatitis caused by Staphylococcus aureus infection and its association with MBL2 gene polymorphisms and its serum level in a sample of Iraqi patients,” supervised by Professor Dr. Bushra Jassim Mohammed.
The study aimed to highlight the relationship between recurrent Staphylococcus aureus infections and the occurrence of atopic dermatitis, with a focus on the role of genetic variations in the MBL2 gene and their impact on the immune response. It also included measuring the level of MBL protein in patients’ serum and comparing it with healthy individuals, as well as analyzing the association between different genotypes of the gene and the severity and recurrence of the disease.
The results showed a significant decrease in MBL protein levels in patients compared to healthy controls, indicating its potential role in increasing susceptibility to the disease. The findings also demonstrated a clear association between MBL2 gene polymorphisms and the risk of atopic dermatitis, with variations in protein levels depending on the genotype.
Furthermore, the results confirmed an inverse correlation between protein levels and genetic variations, supporting the hypothesis that genetic factors influence the regulation of the immune response.
The study recommended expanding genetic and immunological research to gain a deeper understanding of the role of the MBL2 gene in skin diseases. It also emphasized the importance of using immunological and genetic markers in early diagnosis and in determining disease severity. Additionally, it suggested monitoring MBL protein levels as a supportive factor in assessing disease status, encouraging further studies on larger and more diverse populations to enhance accuracy, and developing therapeutic strategies based on the molecular and genetic understanding of the disease.
